HandBrake Tutorial: How to Compress Video Without Quality Loss

To get high-quality MP4 and MKV videos in HandBrake without creating unnecessarily massive file sizes, you should always use Constant Quality (CRF/RF) mode instead of an average bitrate. The best settings depend primarily on the resolution of your source video. The Core Video Settings

To achieve visually lossless quality, configure your Video tab with the following baseline targets: